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Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia.

Abstract:

Hepatitis C virus (HCV) is associated with B-cell lymphoproliferative disorders such as mixed cryoglobulinemia (MC) and B-cell non-Hodgkin lymphoma (B-NHL). The pathogenesis of these disorders remains unclear, and it has been proposed that HCV drives the pro-liferation of B cells. Here we demonstrate that certain HCV(+)MC(+) subjects have clonal expansions of immunoglobulin M (IgM)(+)kappa(+)IgD(low/-)CD21(low)CD27(+) B cells. Using RT-PCR to amplify Ig from these singly sorted cells, we show...

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Journal:
Blood
Volume:
111
Issue:
3
Pages:
1344-1356
Publication date:
2008-02-29
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:5d2a18b7-1562-4099-a9ce-746d854d5132
Source identifiers:
426225
Local pid:
pubs:426225

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