- Abstract:
-
Hepatitis C virus (HCV) is associated with B-cell lymphoproliferative disorders such as mixed cryoglobulinemia (MC) and B-cell non-Hodgkin lymphoma (B-NHL). The pathogenesis of these disorders remains unclear, and it has been proposed that HCV drives the pro-liferation of B cells. Here we demonstrate that certain HCV(+)MC(+) subjects have clonal expansions of immunoglobulin M (IgM)(+)kappa(+)IgD(low/-)CD21(low)CD27(+) B cells. Using RT-PCR to amplify Ig from these singly sorted cells, we show...
Expand abstract - Publisher copy:
- 10.1182/blood-2007-07-101717
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- Journal:
- Blood
- Volume:
- 111
- Issue:
- 3
- Pages:
- 1344-1356
- Publication date:
- 2008-02-29
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- URN:
-
uuid:5d2a18b7-1562-4099-a9ce-746d854d5132
- Source identifiers:
-
426225
- Local pid:
- pubs:426225
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia.
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