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Journal article

Mutations within lncRNAs are effectively selected against in fruitfly but not in human.

Abstract:

BACKGROUND: Previous studies in Drosophila and mammals have revealed levels of long non-coding RNAs (lncRNAs) sequence conservation that are intermediate between neutrally evolving and protein-coding sequence. These analyses compared conservation between species that diverged up to 75 million years ago. However, analysis of sequence polymorphisms within a species' population can provide an understanding of essentially contemporaneous selective constraints that are acting on lncRNAs and can qu...

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Publication status:
Published online

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Publisher copy:
10.1186/gb-2013-14-5-r49

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Genome biology
Volume:
14
Issue:
5
Pages:
R49
Chapter number:
ARTN R49
Publication date:
2013-01-05
DOI:
EISSN:
1474-760X
ISSN:
1474-7596
URN:
uuid:5d29cdba-5a6c-4146-a66a-102391ed26e4
Source identifiers:
401166
Local pid:
pubs:401166

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