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The bovine alveolar macrophage DNA methylome is resilient to infection with Mycobacterium bovis

Abstract:

DNA methylation is pivotal in orchestrating gene expression patterns in various mammalian biological processes. Perturbation of the bovine alveolar macrophage (bAM) transcriptome, due to Mycobacterium bovis (M. bovis) infection, has been well documented; however, the impact of this intracellular pathogen on the bAM epigenome has not been determined. Here, whole genome bisulfite sequencing (WGBS) was used to assess the effect of M. bovis infection on the bAM DNA methylome. The methylomes of bA...

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Publication status:
Not Published
Peer review status:
Not peer reviewed
Version:
Author's Original

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Publisher copy:
10.1101/238816

Authors


O'Doherty, A More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
ORCID:
0000-0003-3899-3872
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ORCID:
0000-0002-6137-1716
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DOI:
Pubs id:
pubs:942202
URN:
uri:5d29c848-202c-46a8-a4fa-2c7d76761ace
UUID:
uuid:5d29c848-202c-46a8-a4fa-2c7d76761ace
Local pid:
pubs:942202
Keywords:

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