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DeFries-Fulker analysis of twin data with skewed distributions: cautions and recommendations from a study of children's use of verb inflections

Abstract:

DeFries-Fulker (DF) analysis is an adaptation of multiple regression that is used to estimate heritability of extreme scores (h²g) on a dimension. Probands are identified as scoring below a cutoff that defines impairment, and one then uses regression to predict the scores of co-twins from the proband scores and a term that denotes the genetic relationship between twins (1.0 for MZ and 0.5 for DZ twins). This paper reports illustrative data and simulations for the situation where th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s10519-004-1834-7

Authors


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Institution:
University of Oxford
Department:
Medical Sciences Division - Experimental Psychology
Role:
Author
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Funding agency for:
D. V. M. Bishop
Publisher:
Springer Publisher's website
Journal:
Behavior Genetics Journal website
Volume:
35
Issue:
4
Pages:
479-490
Publication date:
2005-07-05
DOI:
EISSN:
1573-3297
ISSN:
0001-8244
URN:
uuid:5d19271a-057c-4870-b904-bc3994bbfcd4
Local pid:
ora:4178

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