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Tenascin-C fragments are endogenous inducers of cartilage matrix degradation.

Abstract:

Cartilage destruction is a hallmark of osteoarthritis (OA) and is characterized by increased protease activity resulting in the degradation of critical extracellular matrix (ECM) proteins essential for maintaining cartilage integrity. Tenascin-C (TN-C) is an ECM glycoprotein, and its expression is upregulated in OA cartilage. We aimed to investigate the presence of TN-C fragments in arthritic cartilage and establish whether they promote cartilage degradation. Expression of TN-C and its fragme...

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Publisher copy:
10.1007/s00296-011-2067-8

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Journal:
Rheumatology international
Volume:
32
Issue:
9
Pages:
2809-2817
Publication date:
2012-09-05
DOI:
EISSN:
1437-160X
ISSN:
0172-8172
URN:
uuid:5d1664ec-b74e-4737-acdf-6540aa2d9030
Source identifiers:
230496
Local pid:
pubs:230496

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