Tenascin-C fragments are endogenous inducers of cartilage matrix degradation.

Journal article

Cartilage destruction is a hallmark of osteoarthritis (OA) and is characterized by increased protease activity resulting in the degradation of critical extracellular matrix (ECM) proteins essential for maintaining cartilage integrity. Tenascin-C (TN-C) is an ECM glycoprotein, and its expression is upregulated in OA cartilage. We aimed to investigate the presence of TN-C fragments in arthritic cartilage and establish whether they promote cartilage degradation. Expression of TN-C and its fragme...

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Authors: Sofat, N; Robertson, S; Hermansson, M; Jones, J; Mitchell, P

• Journal: Rheumatology international
• Volume: 32
• Issue: 9
• Pages: 2809-2817
• Publication date: 2012-09-01
• DOI: 10.1007/s00296-011-2067-8
• EISSN: 1437-160X
• ISSN: 0172-8172
• Language: English
• Keywords: Cartilage, Articular; Models, Animal; Osteoarthritis; Swine; Up-Regulation; Glycosaminoglycans; Peptide Fragments; Tenascin; Matrix Metalloproteinases; Arthritis, Rheumatoid; Endopeptidases; Humans; Animals