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The heme auxotroph Caenorhabditis elegans can cleave the thioether bonds of c‐type cytochromes

Abstract:

Heme is essential and synthesized via highly regulated processes. For this reason, most organisms strive to recycle it or acquire it from their environment. When heme is bound to proteins noncovalently, degradation of the polypeptide is sufficient to release it. However, in some hemoproteins, such as c‐type cytochromes, heme is covalently bound to the protein backbone. We use the heme auxotroph Caenorhabditis elegans to investigate if cytochromes c can be a heme source, and we show that this ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1002/1873-3468.13006

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More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
St Edmund Hall
Role:
Author
More from this funder
Funding agency for:
Mavridou, DAI
Publisher:
Wiley Publisher's website
Journal:
FEBS Letters Journal website
Volume:
592
Issue:
6
Pages:
928-938
Publication date:
2018-03-01
Acceptance date:
2018-01-26
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Pubs id:
pubs:826243
URN:
uri:5d0d9a0b-42e1-4556-b716-51482c0f0660
UUID:
uuid:5d0d9a0b-42e1-4556-b716-51482c0f0660
Local pid:
pubs:826243

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