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Mesenchymal stromal cells as anti-inflammatory and regenerative mediators for donor kidneys during normothermic machine perfusion

Abstract:

There is great demand for transplant kidneys for the treatment of end-stage kidney disease patients. To expand the donor pool, organs from older and comorbid brain death donors, so-called expanded criteria donors (ECD), as well as donation after circulatory death donors, are considered for transplantation. However, the quality of these organs may be inferior to standard donor organs. A major issue affecting graft function and survival is ischemia/reperfusion injury, which particularly affects...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1089/scd.2017.0030

Authors


Sierra-Parraga, JM More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
ORCID:
0000-0002-4972-6879
Leuvenink, H More by this author
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Publisher:
Mary Ann Liebert Publisher's website
Journal:
Stem Cells and Development Journal website
Volume:
26
Issue:
16
Pages:
1162-1170
Publication date:
2017-08-15
Acceptance date:
2017-05-29
DOI:
EISSN:
1557-8534
ISSN:
1547-3287
Pubs id:
pubs:702430
URN:
uri:5d0b6f42-f600-48cd-b5f0-3b5a292ca0e9
UUID:
uuid:5d0b6f42-f600-48cd-b5f0-3b5a292ca0e9
Local pid:
pubs:702430

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