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Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism.

Abstract:

IL-10 is a potent anti-inflammatory molecule, which regulates TNF-alpha at multiple levels. We investigated whether IL-10 also modulated the activity of the TNF-alpha-converting enzyme (TACE). Using an ex vivo fluorogenic assay we observed that LPS rapidly induced TACE activity in monocytes coinciding with release of soluble TNF-alpha. In the presence of IL-10, TNF-alpha production and activation of surface TACE was significantly inhibited. Paradoxically, both LPS with or without IL-10 led to...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200737821

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Robertshaw, HJ More by this author
Alvarez-Iglesias, M More by this author
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Journal:
European journal of immunology
Volume:
38
Issue:
4
Pages:
1106-1117
Publication date:
2008-04-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:5d0b4101-c0c0-497f-956a-6668df09603e
Source identifiers:
223924
Local pid:
pubs:223924

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