Journal article
Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability
- Abstract:
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Mutations within BRCA1 predispose carriers to a high risk of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through the assembly of multiple protein complexes involved in DNA repair, cell-cycle arrest, and transcriptional regulation. Here, we report the identification of a DNA damage-induced BRCA1 protein complex containing BCLAF1 and other key components of the mRNA-splicing machinery. In response to DNA damage, this complex regulates pre-mRNA splicing of a number ...
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- Publisher copy:
- 10.1016/j.molcel.2014.03.021
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Authors
Bibliographic Details
- Journal:
- Molecular Cell
- Volume:
- 54
- Issue:
- 3
- Pages:
- 445-459
- Publication date:
- 2014-05-08
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- Source identifiers:
-
465688
Item Description
- Pubs id:
-
pubs:465688
- UUID:
-
uuid:5d02dca5-ce6a-4e32-a66c-2801f70ffc3d
- Local pid:
- pubs:465688
- Deposit date:
- 2014-09-14
Terms of use
- Copyright date:
- 2014
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