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Dihydroartemisinin-piperaquine versus artesunate-amodiaquine: superior efficacy and posttreatment prophylaxis against multidrug-resistant Plasmodium falciparum and Plasmodium vivax malaria.

Abstract:

BACKGROUND: Antimalarial drug resistance is now well established in both Plasmodium falciparum and Plasmodium vivax. In southern Papua, Indonesia, where both strains of plasmodia coexist, we have been conducting a series of studies to optimize treatment strategies. METHODS: We conducted a randomized trial that compared the efficacy and safety of dihydroartemisinin-piperaquine (DHP) with artesunate-amodiaquine (AAQ). The primary end point was the overall cumulative parasitological failure rat...

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Publication status:
Published

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Publisher copy:
10.1086/512677

Authors


Hasugian, AR More by this author
Kenangalem, E More by this author
Wuwung, RM More by this author
Ebsworth, EP More by this author
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Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume:
44
Issue:
8
Pages:
1067-1074
Publication date:
2007-04-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:5cfc850d-6bb1-4866-a097-28f3e628fd6c
Source identifiers:
61508
Local pid:
pubs:61508

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