Functional role of 64P, the candidate transmission-blocking vaccine antigen from the tick, Rhipicephalus appendiculatus.

Journal article

Anti-ectoparasite vaccines offer attractive alternatives to the use of chemical pesticides, especially if they also control the pathogens that ectoparasites transmit. However, selection of suitable antigens is a major constraint on vaccine development. The recombinant tick cement protein, 64TRP, derived from the African brown ear tick, Rhipicephalus appendiculatus, acts as a transmission-blocking vaccine in a mouse model of tick-borne encephalitis virus (TBEV) transmission, protecting immunis...

Expand abstract

Authors: Havlíková, S; Roller, L; Koci, J; Trimnell, A; Kazimírová, M

• Publication status: Published
• Journal: International journal for parasitology
• Volume: 39
• Issue: 13
• Pages: 1485-1494
• Publication date: 2009-11-01
• DOI: 10.1016/j.ijpara.2009.05.005
• EISSN: 1879-0135
• ISSN: 0020-7519
• Language: English
• Keywords: Rhipicephalus; Polymerase Chain Reaction; DNA, Complementary; Tick Infestations; Male; Female; Mice; Recombinant Proteins; Cricetinae; Animals; Salivary Glands; Antigens; Vaccines; Molecular Sequence Data; Guinea Pigs