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The effect of varying analytical methods on estimates of anti-malarial clinical efficacy.

Abstract:

BACKGROUND: Analytical approaches for the interpretation of anti-malarial clinical trials vary considerably. The aim of this study was to quantify the magnitude of the differences between efficacy estimates derived from these approaches and identify the factors underlying these differences. METHODS: Data from studies conducted in Africa and Thailand were compiled and the risk estimates of treatment failure, adjusted and unadjusted by genotyping, were derived by three methods (intention to tr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1475-2875-8-77

Authors


Verret, WJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Funding agency for:
Nosten, F
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Funding agency for:
Price, RN
Wellcome Trust More from this funder
National Institutes of Health More from this funder
Centers for Disease Control and Prevention More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Malaria Journal Journal website
Volume:
8
Issue:
1
Pages:
Article: 77
Publication date:
2009
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
URN:
uuid:5cf659eb-b4bc-44a4-a9a9-afe1e104edb1
Source identifiers:
2932
Local pid:
pubs:2932

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