- Abstract:
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Obesity is a global epidemic that is causally associated with a range of diseases, including type 2 diabetes and cardiovascular disease, at the population-level. However, there is marked heterogeneity in obesity-related outcomes among individuals. This might reflect genotype-dependent responses to adiposity. Given that adiposity, measured by BMI, is associated with widespread changes in gene expression and regulatory variants mediate the majority of known complex trait loci, we sought to iden...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.2MB)
-
- Publisher copy:
- 10.1016/j.ajhg.2016.07.001
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- American Journal of Human Genetics Journal website
- Volume:
- 99
- Issue:
- 3
- Pages:
- 567-579
- Publication date:
- 2016-09-05
- Acceptance date:
- 2016-07-01
- DOI:
- EISSN:
-
1537-6605
- ISSN:
-
0002-9297
- Pubs id:
-
pubs:691942
- URN:
-
uri:5cf10be3-38ae-439f-9964-4c5827f16854
- UUID:
-
uuid:5cf10be3-38ae-439f-9964-4c5827f16854
- Local pid:
- pubs:691942
- Copyright holder:
- Glastonbury et al
- Copyright date:
- 2016
- Notes:
- © 2016 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Journal article
Adiposity-dependent regulatory effects on multi-tissue transcriptomes.
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National Institute for Health Research
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