- Abstract:
-
We propose that amyotrophic lateral sclerosis (ALS), and frontotemporal dementia may be viewed as a failure of interlinked functional complexes having their origins in key evolutionary adaptations. We discuss how hand-arm function, locomotion, brainstem function (involving vocalization/speech, swallowing and breathing), and cognitive impairment share complex, interdependent evolutionary adaptations that can be traced back several million years. Fine movements of the hand facilitated tool-maki...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/mus.24132
-
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- Journal:
- Muscle and nerve
- Volume:
- 49
- Issue:
- 4
- Pages:
- 469-477
- Publication date:
- 2014-04-05
- DOI:
- EISSN:
-
1097-4598
- ISSN:
-
0148-639X
- URN:
-
uuid:5cd2baaf-9f38-40d3-98a6-0f3e029fc253
- Source identifiers:
-
445233
- Local pid:
- pubs:445233
- Language:
- English
- Keywords:
- Copyright date:
- 2014
Journal article
Tools and talk: an evolutionary perspective on the functional deficits associated with amyotrophic lateral sclerosis.
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