Transplantation of human fetal mesenchymal stem cells improves glomerulopathy in a collagen type I alpha 2-deficient mouse.

Journal article

Fetal mesenchymal stem cell (fetal MSC) therapy has potential to treat genetic diseases with early onset, including those affecting the kidney and urinary tract. A collagen type I alpha 2-deficient mouse has a deletion in the alpha2 chain of the procollagen type I gene, resulting in the synthesis of abnormal alpha1(I)(3) homotrimers, which replace normal alpha 1(I)2 alpha 2(I)1 heterotrimers and a glomerulopathy. We first confirmed that col1 alpha 2-deficient homozygous mice show abnormal col...

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Authors: Guillot, P; Cook, H; Pusey, C; Fisk, N; Harten, S

• Publication status: Published
• Journal: Journal of pathology
• Volume: 214
• Issue: 5
• Pages: 627-636
• Publication date: 2008-04-01
• DOI: 10.1002/path.2325
• EISSN: 1096-9896
• ISSN: 0022-3417
• Language: English
• Keywords: Fetal Therapies; Female; Fetal Stem Cells; Kidney Glomerulus; Collagen Type I; Disease Models, Animal; Animals; Male; Kidney Diseases; Microscopy, Electron; Mice; Humans; Graft Survival; Fetal Diseases; Mesenchymal Stem Cell Transplantation