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Journal article

Transplantation of human fetal mesenchymal stem cells improves glomerulopathy in a collagen type I alpha 2-deficient mouse.

Abstract:

Fetal mesenchymal stem cell (fetal MSC) therapy has potential to treat genetic diseases with early onset, including those affecting the kidney and urinary tract. A collagen type I alpha 2-deficient mouse has a deletion in the alpha2 chain of the procollagen type I gene, resulting in the synthesis of abnormal alpha1(I)(3) homotrimers, which replace normal alpha 1(I)2 alpha 2(I)1 heterotrimers and a glomerulopathy. We first confirmed that col1 alpha 2-deficient homozygous mice show abnormal col...

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Publication status:
Published

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Publisher copy:
10.1002/path.2325

Authors


Guillot, PV More by this author
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Journal:
The Journal of pathology
Volume:
214
Issue:
5
Pages:
627-636
Publication date:
2008-04-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:5cd0bde9-a6d1-429a-9f41-3be7061973bc
Source identifiers:
223523
Local pid:
pubs:223523

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