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Evaluation of methylation status of the eNOS promoter at birth in relation to childhood bone mineral content.

Abstract:

Our previous work has shown associations between childhood adiposity and perinatal methylation status of several genes in umbilical cord tissue, including endothelial nitric oxide synthase (eNOS). There is increasing evidence that eNOS is important in bone metabolism; we therefore related the methylation status of the eNOS gene promoter in stored umbilical cord to childhood bone size and density in a group of 9-year-old children. We used Sequenom MassARRAY to assess the methylation status of ...

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Publication status:
Published

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Publisher copy:
10.1007/s00223-011-9554-5

Authors


Harvey, NC More by this author
Lillycrop, KA More by this author
Garratt, E More by this author
Sheppard, A More by this author
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Journal:
Calcified tissue international
Volume:
90
Issue:
2
Pages:
120-127
Publication date:
2012-02-05
DOI:
EISSN:
1432-0827
ISSN:
0171-967X
URN:
uuid:5cc883b8-a2c8-41a2-9960-c380b9edf660
Source identifiers:
221304
Local pid:
pubs:221304

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