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Journal article

Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE⁻/⁻ mice.

Abstract:

AIMS: Vascular disease states are associated with endothelial dysfunction and increased production of reactive oxygen species derived from NADPH oxidases. However, it remains unclear whether a primary increase in superoxide production specifically in the endothelium alters the initiation or progression of atherosclerosis. METHODS AND RESULTS: Mice overexpressing Nox2 specifically in the endothelium (Nox2-Tg) were crossed with ApoE(-/-) mice to produce Nox2-Tg ApoE(-/-) mice and ApoE(-/-) litt...

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Publication status:
Published

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Publisher copy:
10.1093/cvr/cvs026

Authors


Douglas, G More by this author
Bendall, JK More by this author
Crabtree, MJ More by this author
Tatham, AL More by this author
Carter, EE More by this author
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Journal:
Cardiovascular research
Volume:
94
Issue:
1
Pages:
20-29
Publication date:
2012-04-05
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
URN:
uuid:5cb858e1-54aa-4fe2-98bd-a2a6e0b352a4
Source identifiers:
245882
Local pid:
pubs:245882

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