Journal article
Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE⁻/⁻ mice.
- Abstract:
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AIMS: Vascular disease states are associated with endothelial dysfunction and increased production of reactive oxygen species derived from NADPH oxidases. However, it remains unclear whether a primary increase in superoxide production specifically in the endothelium alters the initiation or progression of atherosclerosis. METHODS AND RESULTS: Mice overexpressing Nox2 specifically in the endothelium (Nox2-Tg) were crossed with ApoE(-/-) mice to produce Nox2-Tg ApoE(-/-) mice and ApoE(-/-) litt...
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- Publication status:
- Published
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(pdf, 455.9KB)
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- Publisher copy:
- 10.1093/cvr/cvs026
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Bibliographic Details
- Journal:
- Cardiovascular research
- Volume:
- 94
- Issue:
- 1
- Pages:
- 20-29
- Publication date:
- 2012-04-05
- DOI:
- EISSN:
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1755-3245
- ISSN:
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0008-6363
- URN:
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uuid:5cb858e1-54aa-4fe2-98bd-a2a6e0b352a4
- Source identifiers:
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245882
- Local pid:
- pubs:245882
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2012
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