- Abstract:
-
AIMS: Vascular disease states are associated with endothelial dysfunction and increased production of reactive oxygen species derived from NADPH oxidases. However, it remains unclear whether a primary increase in superoxide production specifically in the endothelium alters the initiation or progression of atherosclerosis. METHODS AND RESULTS: Mice overexpressing Nox2 specifically in the endothelium (Nox2-Tg) were crossed with ApoE(-/-) mice to produce Nox2-Tg ApoE(-/-) mice and ApoE(-/-) litt...
Expand abstract - Publication status:
- Published
- Journal:
- Cardiovascular research
- Volume:
- 94
- Issue:
- 1
- Pages:
- 20-29
- Publication date:
- 2012-04-05
- DOI:
- EISSN:
-
1755-3245
- ISSN:
-
0008-6363
- URN:
-
uuid:5cb858e1-54aa-4fe2-98bd-a2a6e0b352a4
- Source identifiers:
-
245882
- Local pid:
- pubs:245882
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE⁻/⁻ mice.
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