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Aligned electrospun fibers for neural patterning

Abstract:

To test a 3D approach for neural network formation, alignment, and patterning that is reproducible and sufficiently stable to allow for easy manipulation.A novel cell culture system was designed by engineering a method for the directional growth of neurons. This uses NG108-15 neuroblastoma x glioma hybrid cells cultured on suspended and aligned electrospun fibers. These fiber networks improved cellular directionality, with alignment angle standard deviations significantly lower on fibers than...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s10529-017-2494-z

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
ORCID:
0000-0002-3782-9045
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
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China Regenerative Medicine International More from this funder
Clarendon Fund More from this funder
Publisher:
Springer Netherlands Publisher's website
Journal:
Biotechnology Letters Journal website
Volume:
40
Issue:
3
Pages:
601–607
Publication date:
2018-01-08
Acceptance date:
2017-12-13
DOI:
EISSN:
1573-6776
ISSN:
0141-5492
Pubs id:
pubs:817681
URN:
uri:5cab63c4-2dca-45a6-94c3-2404ebf133d2
UUID:
uuid:5cab63c4-2dca-45a6-94c3-2404ebf133d2
Local pid:
pubs:817681

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