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Caffeine modulates Ca2+ receptor activation in isolated rat osteoclasts and induces intracellular Ca2+ release.

Abstract:

A ryanodine-sensitive pathway is involved in intracellular Ca2+ release in response to activation of the osteoclast cell surface Ca2+ receptor. We now report that the ryanodine-receptor modulator, caffeine itself released intracellularly stored Ca2+ and, strongly inhibited Ca2+ release triggered in response to Ca(2+)-receptor activation by Ni2+, a surrogate cation agonist. Caffeine yielded a bell-shaped concentration-response curve (0.005-2 mM) and displayed use-dependent inactivation. Furthe...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
The American journal of physiology
Volume:
268
Issue:
3 Pt 2
Pages:
F447-F454
Publication date:
1995-03-05
ISSN:
0002-9513
URN:
uuid:5c93694d-e61b-4e22-b7a6-bcb606ed347d
Source identifiers:
475708
Local pid:
pubs:475708

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