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Lack of toxicity and persistence in the mouse associated with administration of candidate DNA- and modified vaccinia virus Ankara (MVA)-based HIV vaccines for Kenya.

Abstract:

Toxicity, biodistribution and persistence of candidate HIV vaccines pTHr.HIVA, a recombinant DNA, and MVA.HIVA, a recombinant modified vaccinia virus Ankara, were determined in the Balb/c mouse. The mice were injected with either two doses of intramuscular pTHr.HIVA DNA (50 microg each, separated by an interval of 14 days), two doses of intradermal MVA.HIVA (10(6) plaque-forming units each, separated by an interval of 14 days), or a combination of the two vaccines, each given in two doses, in...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Samuel, RV More by this author
Powell, LA More by this author
McLoughlin, L More by this author
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Journal:
Vaccine
Volume:
21
Issue:
1-2
Pages:
108-114
Publication date:
2002-11-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:5c91b6fc-93c2-49a2-b070-853d20efc43d
Source identifiers:
32253
Local pid:
pubs:32253

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