Journal article icon

Journal article

TNFα blockade in rheumatoid arthritis: Rationale, clinical outcomes and mechanisms of action

Abstract:

Tumor necrosis factor α (TNFα is a cytokine with many biological functions of relevance to inflammatory disease. Although only one of several inflammatory mediators produced in abundance in rheumatoid arthritis (RA), experimental data suggest that it is in a dominant position within a cytokine hierarchy and is therefore a prime target for directed immunotherapy in this disease. We have targeted TNFα in vivo using a chimerised monoclonal anti-TNFα antibody and have now demonstrated beneficial ...

Expand abstract

Actions


Authors


Elliott, MJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
International Journal of Immunopharmacology
Volume:
17
Issue:
2
Pages:
141-145
Publication date:
1995-02-05
ISSN:
0192-0561
URN:
uuid:5c8ba568-1038-4de4-b084-76a19ad80805
Source identifiers:
481807
Local pid:
pubs:481807
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP