Evaluating clinical trial designs for investigational treatments of ebola virus disease
Background: Experimental treatments for Ebola virus disease (EVD) might reduce EVD mortality. There is uncertainty about the ability of different clinical trial designs to identify effective treatments, and about the feasibility of implementing individually randomised controlled trials during an Ebola epidemic.
Methods and findings: A treatment evaluation programme for use in EVD was devised using a multi-stage approach (MSA) with two or three stage...Expand abstract
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- Peer review status:
- Peer reviewed
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- Public Library of Science Publisher's website
- PLoS Medicine Journal website
- Article: e1001815
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- Cooper et al.
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- Copyright © 2015 Cooper et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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