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Evaluating clinical trial designs for investigational treatments of ebola virus disease

Abstract:

Background: Experimental treatments for Ebola virus disease (EVD) might reduce EVD mortality. There is uncertainty about the ability of different clinical trial designs to identify effective treatments, and about the feasibility of implementing individually randomised controlled trials during an Ebola epidemic.

Methods and findings: A treatment evaluation programme for use in EVD was devised using a multi-stage approach (MSA) with two or three stage...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1001815

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine, Viet Nam
Pan-Ngum, W More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Funding agency for:
Boni, MF
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
12
Issue:
4
Pages:
Article: e1001815
Publication date:
2015-04-05
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:5c8b9d98-f6fd-467a-8274-ed727bad7eca
Source identifiers:
518553
Local pid:
pubs:518553
Language:
English

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