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Investigating the genetic association between ERAP1 and ankylosing spondylitis.

Abstract:

A strong association between ERAP1 and ankylosing spondylitis (AS) was recently identified by the Wellcome Trust Case Control Consortium and the Australo-Anglo-American Spondylitis Consortium (WTCCC-TASC) study. ERAP1 is highly polymorphic with strong linkage disequilibrium evident across the gene. We therefore conducted a series of experiments to try to identify the primary genetic association(s) with ERAP1. We replicated the original associations in an independent set of 730 patients and 10...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/hmg/ddp371

Authors


Pointon, JJ More by this author
Karaderi, T More by this author
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Arthritis Research Campaign More from this funder
National Institute for Health Research More from this funder
Canadian Institutes for Health Research More from this funder
Canadian Foundation for Innovation More from this funder
Ontario Genomics Institute More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Human molecular genetics Journal website
Volume:
18
Issue:
21
Pages:
4204-4212
Publication date:
2009-11-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:5c799219-f2f2-4aa3-a2aa-314389dd3c76
Source identifiers:
108752
Local pid:
pubs:108752

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