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A rodent cell line permissive for entry and reverse transcription of human immunodeficiency virus type 1 has a pre-integration block to productive infection.

Abstract:

Replication of human immunodeficiency virus type 1 (HIV-1) is restricted to CD4-expressing primate cells. This tropism may be due partly to the absence from nonprimate cells of a species-specific factor which has an accessory role to CD4 during virus penetration. In this study we describe a rat B lymphocyte cell line in which there is efficient CD4-dependent entry of HIV-1. However, this cell line has a block to productive infection of HIV-1 at a stage between reverse transcription and integr...

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Publication status:
Published

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Authors


Schockmel, GA More by this author
Journal:
The Journal of general virology
Volume:
75 ( Pt 10)
Issue:
10
Pages:
2615-2623
Publication date:
1994-10-05
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:5c6ffe37-4a92-4c62-84de-cf74a50b3ce5
Source identifiers:
7281
Local pid:
pubs:7281

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