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IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling.

Abstract:

Double-stranded RNA-induced antiviral gene expression in mammalian cells requires activation of IFN regulatory factor 3 (IRF3). In this study, we show that the IL-17R adaptor protein Act1/CIKS is involved in this process. Small interfering RNA-mediated knockdown of Act1 in primary human skin fibroblasts specifically attenuates expression of IFN-β and IFN-stimulated antiviral genes induced by a synthetic viral mimic, polyinosinic-polycytidylic acid. Ectopic expression of Act1 potentiates the I...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1200428

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
189
Issue:
10
Pages:
4852-4858
Publication date:
2012-11-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:5c54ea3a-3182-4644-8763-d7157af825e1
Source identifiers:
356275
Local pid:
pubs:356275

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