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Journal article

Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review).

Abstract:

Integrins are heterodimeric membrane-spanning adhesion receptors that are essential for a wide range of biological functions. Control of integrin conformational states is required for bidirectional signalling across the membrane. Key components of this control mechanism are the transmembrane and cytoplasmic domains of the alpha and beta subunits. These domains are believed to interact, holding the integrin in the inactive state, while inside-out integrin activation is accompanied by domain se...

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Publisher copy:
10.1080/09687680802269886

Authors


Journal:
Molecular membrane biology
Volume:
25
Issue:
5
Pages:
376-387
Publication date:
2008-08-05
DOI:
EISSN:
1464-5203
ISSN:
0968-7688
URN:
uuid:5c4baafc-1f7a-465b-9ee0-7009824eaba3
Source identifiers:
246525
Local pid:
pubs:246525

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