Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review).
Integrins are heterodimeric membrane-spanning adhesion receptors that are essential for a wide range of biological functions. Control of integrin conformational states is required for bidirectional signalling across the membrane. Key components of this control mechanism are the transmembrane and cytoplasmic domains of the alpha and beta subunits. These domains are believed to interact, holding the integrin in the inactive state, while inside-out integrin activation is accompanied by domain se...Expand abstract
- Publisher copy:
- Copyright date:
If you are the owner of this record, you can report an update to it here: Report update to this record