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Atrial natriuretic peptide in physiological doses does not inhibit the ACTH or cortisol response to corticotrophin-releasing hormone-41 in normal human subjects.

Abstract:

Whilst it has been postulated that atrial natriuretic peptide (ANP) may modulate pituitary hormone release, several investigations in non-human species have reported conflicting results when looking for an effect on the hypothalamo-pituitary-adrenal axis. However, in a recent study significant inhibition of corticotrophin-releasing hormone (CRH)-stimulated ACTH in cultured rat anterior pituitary cells occurred only with the complete peptide alpha-ANP(1-28). We have therefore investigated whet...

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Publication status:
Published

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Publisher copy:
10.1677/joe.0.1310163

Authors


Tsagarakis, S More by this author
Anderson, JV More by this author
Besser, GM More by this author
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Journal:
The Journal of endocrinology
Volume:
131
Issue:
1
Pages:
163-167
Publication date:
1991-10-05
DOI:
EISSN:
1479-6805
ISSN:
0022-0795
URN:
uuid:5c45a00c-ef73-4b7b-b01d-05493e4129e8
Source identifiers:
138266
Local pid:
pubs:138266

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