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Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere.

Abstract:

We recently reported the presence of four genes lying between the human alpha-globin gene cluster and the telomere of the short arm of chromosome 16 (16p). We now report that one of these genes encodes 3-methyladenine DNA glycosylase, an enzyme important in the repair of DNA after damage by alkylating agents. The gene comprises five exons, representation of which differs in independently isolated cDNA clones. Although the gene is widely expressed, the abundance of its mRNA is considerably hig...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.90.8.3437

Authors


Vickers, MA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research
Harris, PC More by this author
Simmons, DL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
90
Issue:
8
Pages:
3437-3441
Publication date:
1993-04-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:5c437227-daf6-47bd-9e35-70b467cafae3
Source identifiers:
35872
Local pid:
pubs:35872

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