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Multi-center evaluation of the fully automated PCR-based Idylla™ KRAS mutation assay for rapid KRAS mutation status determination on formalin-fixed paraffin-embedded tissue of human colorectal cancer

Abstract:

Since the advent of monoclonal antibodies against epidermal growth factor receptor (EGFR) in colorectal cancer therapy, the determination of RAS mutational status is needed for therapeutic decision-making. Most prevalent in colorectal cancer are KRAS exon 2 mutations (40% prevalence); lower prevalence is observed for KRAS exon 3 and 4 mutations (6%) and NRASexon 2, 3, and 4 mutations (5%). The Idylla KRAS Mutation Test on the molecular diagnostics Idy...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pone.0163444

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Role:
Author
ORCID:
0000-0002-0293-6158
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Role:
Author
ORCID:
0000-0002-7704-850X
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS ONE Journal website
Volume:
11
Issue:
9
Pages:
Article: e0163444
Publication date:
2016-09-29
Acceptance date:
2016-09-07
DOI:
EISSN:
1932-6203
Pubs id:
pubs:647636
URN:
uri:5c4025e5-5f20-4d22-8dc6-f28193d451aa
UUID:
uuid:5c4025e5-5f20-4d22-8dc6-f28193d451aa
Local pid:
pubs:647636
Language:
English

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