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Hippocampal theta input to the amygdala shapes feedforward inhibition to gate heterosynaptic plasticity

Abstract:

The dynamic interactions between hippocampus and amygdala are critical for emotional memory. Theta synchrony between these structures occurs during fear memory retrieval and may facilitate synaptic plasticity, but the cellular mechanisms are unknown. We report that interneurons of the mouse basal amygdala are activated during theta network activity or optogenetic stimulation of ventral CA1 pyramidal cell axons, whereas principal neurons are inhibited. Interneurons provide feedforward inhibiti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.neuron.2015.08.024

Authors


Bazelot, M More by this author
More by this author
Department:
Oxford, MSD, Pharmacology
Kasugai, Y More by this author
Fischer, D More by this author
More by this author
Department:
Oxford, MSD, Pharmacology, BNDU
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Medical Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Elsevier Inc. Publisher's website
Journal:
Neuron Journal website
Volume:
87
Issue:
6
Pages:
1290-1303
Publication date:
2015-09-23
Acceptance date:
2015-08-07
DOI:
ISSN:
0896-6273 and 1097-4199
Pubs id:
pubs:568413
URN:
uri:5c3704c7-f42f-4223-aa3f-adf1eef0897f
UUID:
uuid:5c3704c7-f42f-4223-aa3f-adf1eef0897f
Local pid:
pubs:568413

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