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Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens.

Abstract:

Modulation of striatal dopamine (DA) neurotransmission plays a fundamental role in the reinforcing and ultimately addictive effects of nicotine. Nicotine, by desensitizing beta2 subunit-containing (beta2*) nicotinic acetylcholine receptors (nAChRs) on striatal DA axons, significantly enhances how DA is released by reward-related burst activity compared to nonreward-related tonic activity. This action provides a synaptic mechanism for nicotine to facilitate the DA-dependent reinforcement. The ...

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Publication status:
Published

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Publisher copy:
10.1038/sj.npp.1301617

Authors


Clements, MA More by this author
Hartung, H More by this author
McIntosh, JM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume:
33
Issue:
9
Pages:
2158-2166
Publication date:
2008-08-05
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
URN:
uuid:5c35f423-5c8b-4613-887d-1a1b17e7b530
Source identifiers:
114097
Local pid:
pubs:114097

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