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Journal article

Glycolipid receptor depletion as an approach to specific antimicrobial therapy.

Abstract:

Mucosal pathogens recognize glycoconjugate receptors at the site of infection, and attachment is an essential first step in disease pathogenesis. Inhibition of attachment may prevent disease, and several approaches have been explored. This review discusses the prevention of bacterial attachment and disease by agents that modify the glycosylation of cell surface glycoconjugates. Glycosylation inhibitors were tested in the urinary tract infection model, where P-fimbriated Escherichia coli rely ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
FEMS microbiology letters
Volume:
258
Issue:
1
Pages:
1-8
Publication date:
2006-05-05
DOI:
EISSN:
1574-6968
ISSN:
0378-1097
URN:
uuid:5c34c538-6519-485e-ade6-dea5f7eb3314
Source identifiers:
185138
Local pid:
pubs:185138

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