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Journal article

Activation of 5-HT(6) receptors facilitates attentional set shifting.

Abstract:

RATIONALE: Prefrontal cortex (PFC)-dependent executive function is disrupted in a range of psychiatric disorders and can be modelled in non-human primates and rodents using attentional set-shifting paradigms. There are few current pharmacological strategies for enhancing attentional set shifting, although the PFC is rich in relevant neurotransmitter targets, including 5-hydroxytryptamine (5-HT). Although 5-HT depletion studies do not support a role for 5-HT in attentional set shifting, the ef...

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Publication status:
Published

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Publisher copy:
10.1007/s00213-009-1701-6

Authors


Burnham, KE More by this author
Baxter, MG More by this author
Bainton, JR More by this author
Southam, E More by this author
Dawson, LA More by this author
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Journal:
Psychopharmacology
Volume:
208
Issue:
1
Pages:
13-21
Publication date:
2010-01-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:5c2b8ae1-62f2-4b03-80fd-4febabcb58a2
Source identifiers:
55
Local pid:
pubs:55

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