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Morphogen gradient from a noisy source.

Abstract:
We investigate the effect of time-dependent noise on the shape of a morphogen gradient in a developing embryo. Perturbation theory is used to calculate the deviations from deterministic behavior in a simple reaction-diffusion model of robust gradient formation, and the results are confirmed by numerical simulation. It is shown that such deviations can disrupt robustness for sufficiently high noise levels, and the implications of these findings for more complex models of gradient-shaping pathways are discussed.

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Journal:
Physical review letters
Volume:
94
Issue:
7
Pages:
078101
Publication date:
2005-02-05
DOI:
EISSN:
1079-7114
ISSN:
0031-9007
URN:
uuid:5c26b626-659f-424b-be90-b190b9bfd679
Source identifiers:
240720
Local pid:
pubs:240720

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