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Murine IL-10 gene transfer inhibits established collagen-induced arthritis and reduces adenovirus-mediated inflammatory responses in mouse liver.

Abstract:

The effects of homologous IL-10 administration during an established autoimmune disease are controversial, given its reported immunostimulatory and immunosuppressive properties. Studies of collagen-induced arthritis have shown efficacy with repeated administrations of IL-10; however, when the EBV IL-10 homologue was administered via adenovirus gene transfer technology the results were equivocal. Therefore, the present study was undertaken to elucidate the effects of prolonged homologous IL-10...

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Publication status:
Published

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Authors


Quattrocchi, E More by this author
Dallman, MJ More by this author
Dhillon, AP More by this author
Quaglia, A More by this author
Bagnato, G More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
166
Issue:
10
Pages:
5970-5978
Publication date:
2001-05-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:5c19adf0-f411-4f03-a0c7-cc3cdac01638
Source identifiers:
224144
Local pid:
pubs:224144

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