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Limitation of Trypanosoma brucei parasitaemia results from density-dependent parasite differentiation and parasite killing by the host immune response.

Abstract:

In the bloodstream of its mammalian host, the "slender" form of Trypanosoma brucei replicates extracellularly, producing a parasitaemia. At high density, the level of parasitaemia is limited at a sublethal level by differentiation to the non-replicative "stumpy" form and by the host immune response. Here, we derive continuous time equations to model the time-course, cell types and level of trypanosome parasitaemia, and compare the best fits with experimental data. The best fits that were obta...

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Publication status:
Published

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Publisher copy:
10.1098/rspb.2001.1794

Authors


Matthews, KR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Proceedings. Biological sciences / The Royal Society
Volume:
268
Issue:
1482
Pages:
2235-2243
Publication date:
2001-11-05
DOI:
EISSN:
1471-2954
ISSN:
0962-8452
URN:
uuid:5bfe2515-63aa-4978-a5a9-7c6ac8bf58d5
Source identifiers:
6134
Local pid:
pubs:6134

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