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A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria.

Abstract:

BACKGROUND: Dihydroartemisinin-piperaquine (DP) is a fixed-combination antimalarial drug increasingly deployed in Southeast Asia. The current regimen involves 4 doses given over 3 days. Simplification of the dose regimen should facilitate treatment adherence and thereby increase effectiveness. METHODS: In a randomized, controlled, 3-arm trial conducted along the northwestern border of Thailand, the standard 4-dose course of DP (DP4) was compared to an equivalent dose given as a once-daily re...

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Publication status:
Published

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Publisher copy:
10.1086/432011

Authors


Ashley, EA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Hutagalung, R More by this author
Phaiphun, L More by this author
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Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume:
41
Issue:
4
Pages:
425-432
Publication date:
2005-08-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:5bfad33f-a4c3-4f1a-bef3-c59331368b1c
Source identifiers:
28644
Local pid:
pubs:28644

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