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Physical training for McArdle disease.

Abstract:

BACKGROUND: McArdle disease is a rare metabolic myopathy caused by a complete absence of the enzyme muscle glycogen phosphorylase. Affected people experience symptoms of fatigue and cramping within minutes of exercise and are at risk for acute muscle injury (rhabdomyolysis) and acute renal failure. If the first few minutes of exercise are paced, a 'second wind' will occur enabling exercise to continue. This is due to mobilisation and utilisation of alternative fuel substrates. Aerobic traini...

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Authors


Quinlivan, R More by this author
Vissing, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Buckley, J More by this author
Journal:
The Cochrane database of systematic reviews
Issue:
12
Pages:
CD007931
Publication date:
2011
DOI:
EISSN:
1469-493X
ISSN:
1469-493X
URN:
uuid:5bf8016d-5c25-4ffb-b557-50da9a122c85
Source identifiers:
240973
Local pid:
pubs:240973
Language:
English
Keywords:

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