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Timing is everything: the regulation of type III secretion.

Abstract:

Type Three Secretion Systems (T3SSs) are essential virulence determinants of many Gram-negative bacteria. The T3SS is an injection device that can transfer bacterial virulence proteins directly into host cells. The apparatus is made up of a basal body that spans both bacterial membranes and an extracellular needle that possesses a channel that is thought to act as a conduit for protein secretion. Contact with a host-cell membrane triggers the insertion of a pore into the target membrane, and ...

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Publication status:
Published

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Publisher copy:
10.1007/s00018-009-0230-0

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Cellular and molecular life sciences : CMLS
Volume:
67
Issue:
7
Pages:
1065-1075
Publication date:
2010-04-05
DOI:
EISSN:
1420-9071
ISSN:
1420-682X
URN:
uuid:5bf46c36-ecf5-4b9f-b633-45e35962efa2
Source identifiers:
5564
Local pid:
pubs:5564

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