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Rapid evolution of decreased host susceptibility drives a stable relationship between ultrasmall parasite TM7x and its bacterial host

Abstract:

Around one-quarter of bacterial diversity comprises a single radiation with reduced genomes, known collectively as the Candidate Phyla Radiation. Recently, we coisolated TM7x, an ultrasmall strain of the Candidate Phyla Radiation phylum Saccharibacteria, with its bacterial host Actinomyces odontolyticus strain XH001 from human oral cavity and stably maintained as a coculture. Our current work demonstrates that within the coculture, TM7x cells establish a long-term parasitic association with h...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1073/pnas.1810625115

Authors


McLean, JS More by this author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Oxford college:
Magdalen College
ORCID:
0000-0003-4687-6633
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
115
Issue:
48
Pages:
12277-12282
Publication date:
2018-11-15
Acceptance date:
2018-10-24
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:946523
URN:
uri:5bf20c0e-b822-4c0d-a670-2f58984e130a
UUID:
uuid:5bf20c0e-b822-4c0d-a670-2f58984e130a
Local pid:
pubs:946523

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