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Purine metabolism controls innate lymphoid cell function and protects against intestinal injury

Abstract:

Inflammatory bowel disease (IBD) is a condition of chronic inflammatory intestinal disorder with increasing prevalence but limited effective therapies. The purine metabolic pathway is involved in various inflammatory processes including IBD. However, the mechanisms through which purine metabolism modulates IBD remain to be established. Here, we found that mucosal expression of genes involved in the purine metabolic pathway is altered in patients with active ulcerative colitis (UC), which is a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1111/imcb.12167

Authors


Crittenden, S More by this author
Forster, T More by this author
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Funding agency for:
Anderton, SM
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Funding agency for:
Ghazal, P
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Publisher:
Wiley Publisher's website
Journal:
Immunology and Cell Biology Journal website
Volume:
96
Issue:
10
Pages:
1049-1059
Publication date:
2018-05-14
Acceptance date:
2018-05-07
DOI:
ISSN:
1440-1711 and 0818-9641
Pubs id:
pubs:894291
URN:
uri:5be0e471-4436-49cb-b0d3-c85b601c51e2
UUID:
uuid:5be0e471-4436-49cb-b0d3-c85b601c51e2
Local pid:
pubs:894291

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