Journal article icon

Journal article

Regulative germ cell specification in axolotl embryos: a primitive trait conserved in the mammalian lineage.

Abstract:

How germ cells are specified in the embryos of animals has been a mystery for decades. Unlike most developmental processes, which are highly conserved, embryos specify germ cells in very different ways. Curiously, in mouse embryos germ cells are specified by extracellular signals; they are not autonomously specified by maternal germ cell determinants (germ plasm), as are the germ cells in most animal model systems. We have developed the axolotl (Ambystoma mexicanum), a salamander, as an exper...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1098/rstb.2003.1331

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, BHF Centre of Research Excellence
Role:
Author
Expand authors...
Journal:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume:
358
Issue:
1436
Pages:
1371-1379
Publication date:
2003-08-05
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
URN:
uuid:5bd2f7e5-f541-4c72-907c-f7c1cbcafd31
Source identifiers:
106484
Local pid:
pubs:106484

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP