Journal article
Demonstration that endoplasmic reticulum-associated degradation of glycoproteins can occur downstream of processing by endomannosidase.
- Abstract:
-
During quality control in the ER (endoplasmic reticulum), nascent glycoproteins are deglucosylated by ER glucosidases I and II. In the post-ER compartments, glycoprotein endo-α-mannosidase provides an alternative route for deglucosylation. Previous evidence suggests that endomannosidase non-selectively deglucosylates glycoproteins that escape quality control in the ER, facilitating secretion of aberrantly folded as well as normal glycoproteins. In the present study, we employed FOS (free olig...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Biochemical journal
- Volume:
- 438
- Issue:
- 1
- Pages:
- 133-142
- Publication date:
- 2011-08-01
- DOI:
- EISSN:
-
1470-8728
- ISSN:
-
0264-6021
- Source identifiers:
-
172445
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:172445
- UUID:
-
uuid:5bd2202d-f64b-49cf-a743-d692698c6a91
- Local pid:
- pubs:172445
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2011
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