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Demonstration that endoplasmic reticulum-associated degradation of glycoproteins can occur downstream of processing by endomannosidase.

Abstract:

During quality control in the ER (endoplasmic reticulum), nascent glycoproteins are deglucosylated by ER glucosidases I and II. In the post-ER compartments, glycoprotein endo-α-mannosidase provides an alternative route for deglucosylation. Previous evidence suggests that endomannosidase non-selectively deglucosylates glycoproteins that escape quality control in the ER, facilitating secretion of aberrantly folded as well as normal glycoproteins. In the present study, we employed FOS (free olig...

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Publication status:
Published

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Publisher copy:
10.1042/bj20110186

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Journal:
The Biochemical journal
Volume:
438
Issue:
1
Pages:
133-142
Publication date:
2011-08-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:5bd2202d-f64b-49cf-a743-d692698c6a91
Source identifiers:
172445
Local pid:
pubs:172445

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