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Thesis

Characterisation of tissue homing CD8+ T cells in a murine cytomegalovirus model

Abstract:

Experimental T cell-inducing vaccines seek to generate rapidly responsive, tissue-homing, antigen-specific T cells. CMV induces an unusual memory population (memory "inflation") of highly differentiated effector memory CD8+ T cells specific for a subset of epitopes and as such is being tested as a vaccine vector. Clearly understanding of the factors involved in memory inflation and tissue-associated CD8+ T cells generated by CMV will aid vaccine design and is of general relevance for tissu...

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Institution:
University of Oxford
Research group:
Klenerman
Oxford college:
Lincoln College
Department:
Medical Sciences Division - Pathogen Research,The Peter Medawar Building for

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Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Geraldine A O'Hara
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral

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