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Identification and structure of the nerve growth factor binding site on TrkA.

Abstract:

Nerve growth factor (NGF) is involved in the development and maintenance of the nervous system and has been implicated as a possible therapeutic target molecule in a number of neurodegenerative diseases, especially Alzheimer's disease. NGF binds with high affinity to the extracellular region of a tyrosine kinase receptor, TrkA, which comprises three leucine-rich motifs (LRMs), flanked by two cysteine-rich clusters, followed by two immunoglobulin-like (Ig-like) domains. We have expressed the s...

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Publication status:
Published

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Publisher copy:
10.1006/bbrc.2001.4462

Authors


Robertson, AG More by this author
Banfield, MJ More by this author
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Journal:
Biochemical and biophysical research communications
Volume:
282
Issue:
1
Pages:
131-141
Publication date:
2001-03-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:5bb4e906-298c-4acb-9127-6fb8294bf1a8
Source identifiers:
31849
Local pid:
pubs:31849

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