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Permissible and immunogenic HLA-A mismatches: cytotoxic T-cell precursor frequencies reflect graft survival data.

Abstract:

Analysis of the in vivo immunogenicity of single HLA mismatches, in the context of a patient's own human leukocyte antigen (HLA) phenotype, has been used to define permissible and immunogenic HLA mismatches. Kidney graft survival in the case of permissible mismatches was similar to that of completely HLA matched combinations, whereas immunogenic mismatches lead to a significantly poorer graft survival. The present study tested whether such permissible and immunogenic HLA mismatches are reflec...

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Publication status:
Published

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Authors


Roelen, DL More by this author
van Bree, SP More by this author
Doxiadis, II More by this author
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Journal:
Human immunology
Volume:
62
Issue:
7
Pages:
661-667
Publication date:
2001-07-05
DOI:
EISSN:
1879-1166
ISSN:
0198-8859
URN:
uuid:5bb1528d-5a79-4c88-b8ad-6830bac2f1a2
Source identifiers:
136034
Local pid:
pubs:136034

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