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Journal article

Mutations, evolutionary theory and cancer.

Abstract:

When searching for mutations that may be responsible for tumourigenesis and interpreting their significance, molecular oncologists often make a number of implicit assumptions about how and why tumour genotypes develop. These assumptions are based on an underlying classical model of tumourigenesis. The classical model has a number of similarities to models of evolution: given the parallels between the growth of tumours and the evolution of whole organisms, this is to be expected. However, cons...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Journal:
Trends in ecology and evolution
Volume:
8
Issue:
3
Pages:
107-110
Publication date:
1993-03-05
DOI:
EISSN:
1872-8383
ISSN:
0169-5347
URN:
uuid:5bae37d6-df29-453c-960a-c670a1eb87f0
Source identifiers:
44151
Local pid:
pubs:44151
Language:
English

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