Journal article
Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.
- Abstract:
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BACKGROUND: Neuregulin1 (NRG1)-ErbB signaling has been implicated in the pathogenesis of cancer and schizophrenia. We have previously reported that NRG1-stimulated migration of B lymphoblasts is PI3K-AKT1dependent and impaired in patients with schizophrenia and significantly linked to the catechol-o-methyltransferase (COMT) Val108/158Met functional polymorphism. METHODOLOGY/PRINCIPAL FINDINGS: We have now examined AKT1 activation in NRG1-stimulated B lymphoblasts and other cell models and ex...
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- Publication status:
- Published
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(Preview, pdf, 2.3MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0010789
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Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PloS One More from this journal
- Volume:
- 5
- Issue:
- 5
- Article number:
- e10789
- Publication date:
- 2010-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
Item Description
- Language:
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English
- Keywords:
-
- Pubs id:
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pubs:139577
- UUID:
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uuid:5b9a3404-10f3-419c-bf86-30b34c408c98
- Local pid:
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pubs:139577
- Source identifiers:
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139577
- Deposit date:
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2012-12-19
Terms of use
- Copyright date:
- 2010
- Notes:
- This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
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