- Abstract:
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BACKGROUND: Neuregulin1 (NRG1)-ErbB signaling has been implicated in the pathogenesis of cancer and schizophrenia. We have previously reported that NRG1-stimulated migration of B lymphoblasts is PI3K-AKT1dependent and impaired in patients with schizophrenia and significantly linked to the catechol-o-methyltransferase (COMT) Val108/158Met functional polymorphism. METHODOLOGY/PRINCIPAL FINDINGS: We have now examined AKT1 activation in NRG1-stimulated B lymphoblasts and other cell models and ex...
Expand abstract - Publication status:
- Published
- Files:
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(pdf, 2.3mb)
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- Publisher copy:
- 10.1371/journal.pone.0010789
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS One Journal website
- Volume:
- 5
- Issue:
- 5
- Pages:
- Article: e10789
- Publication date:
- 2010
- DOI:
- EISSN:
-
1932-6203
- ISSN:
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1932-6203
- URN:
-
uuid:5b9a3404-10f3-419c-bf86-30b34c408c98
- Source identifiers:
-
139577
- Local pid:
- pubs:139577
- Language:
- English
- Keywords:
- Copyright date:
- 2010
- Notes:
- This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
Journal article
Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.
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National Institute of Mental Health
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Medical Research Council
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University College, Oxford
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