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Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.

Abstract:

BACKGROUND: Neuregulin1 (NRG1)-ErbB signaling has been implicated in the pathogenesis of cancer and schizophrenia. We have previously reported that NRG1-stimulated migration of B lymphoblasts is PI3K-AKT1dependent and impaired in patients with schizophrenia and significantly linked to the catechol-o-methyltransferase (COMT) Val108/158Met functional polymorphism. METHODOLOGY/PRINCIPAL FINDINGS: We have now examined AKT1 activation in NRG1-stimulated B lymphoblasts and other cell models and ex...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0010789

Authors


Ren-Patterson, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
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Funding agency for:
Tunbridge, EM
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Funding agency for:
Tunbridge, EM
National Institute of Mental Health More from this funder
Medical Research Council More from this funder
University College, Oxford More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS One Journal website
Volume:
5
Issue:
5
Pages:
Article: e10789
Publication date:
2010
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:5b9a3404-10f3-419c-bf86-30b34c408c98
Source identifiers:
139577
Local pid:
pubs:139577

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