Journal article icon

Journal article

Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin.

Abstract:

Hypoxia is a key regulatory factor in tumour growth, activating angiogenesis, glycolysis and cell migration. It is readily recognized by the intracellular accumulation of hypoxia-inducible factor 1alpha (HIF1alpha) and HIF2alpha. Accumulation of HIF1alpha and HIF2alpha was detected immunohistochemically in a series of 46 nodular malignant melanomas of the skin (epithelioid cell variant), treated with wide local excision. The results were correlated with vascular density (VD) and expression of...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Melanoma research
Volume:
13
Issue:
5
Pages:
493-501
Publication date:
2003-10-05
DOI:
EISSN:
1473-5636
ISSN:
0960-8931
URN:
uuid:5b87e2be-3e6f-4c16-bf95-27c6aae78705
Source identifiers:
119277
Local pid:
pubs:119277

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP