- Abstract:
-
Hypoxia is a key regulatory factor in tumour growth, activating angiogenesis, glycolysis and cell migration. It is readily recognized by the intracellular accumulation of hypoxia-inducible factor 1alpha (HIF1alpha) and HIF2alpha. Accumulation of HIF1alpha and HIF2alpha was detected immunohistochemically in a series of 46 nodular malignant melanomas of the skin (epithelioid cell variant), treated with wide local excision. The results were correlated with vascular density (VD) and expression of...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1097/00008390-200310000-00008
-
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- Journal:
- Melanoma research
- Volume:
- 13
- Issue:
- 5
- Pages:
- 493-501
- Publication date:
- 2003-10-05
- DOI:
- EISSN:
-
1473-5636
- ISSN:
-
0960-8931
- URN:
-
uuid:5b87e2be-3e6f-4c16-bf95-27c6aae78705
- Source identifiers:
-
119277
- Local pid:
- pubs:119277
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin.
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