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Angiogenesis as a therapeutic target in arthritis in 2011: learning the lessons of the colorectal cancer experience.

Abstract:

The paradigm of a therapy aimed at inhibiting the formation of blood vessels, which would consequentially deprive cells and tissues of oxygen and nutrients, was born from the concept pioneered by the late Judah Folkman that blood vessel formation is central to the progression and maintenance of diseases which involve cellular metabolism and tissue expansion, and cancer in particular. The prototype targeted angiogenesis inhibitor anti-vascular endothelial growth factor (VEGF) antibody bevacizu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1007/s10456-011-9208-2

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
Publisher:
Springer Verlag Publisher's website
Journal:
Angiogenesis Journal website
Volume:
14
Issue:
3
Pages:
223-234
Publication date:
2011-03-23
DOI:
EISSN:
1573-7209
ISSN:
0969-6970
URN:
uuid:5b7b0b7d-838b-48c8-88dd-eb3f7202542b
Source identifiers:
265425
Local pid:
pubs:265425

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